# Scientists reveal how cosignaling receptors dually regulate T cell activation via phase separation

- Source: Phys.org - latest science and technology news stories
- Published: 2026-11-05T00:20:01+00:00
- Category: Science
- Original: https://phys.org/news/2026-11-scientists-reveal-cosignaling-receptors-dually.html
- Canonical: https://groundlevelnews.com/story/scientists-reveal-how-cosignaling-receptors-dually-regulate-t-cell-act-2d9b4f/

Previous studies have shown that upon antigen stimulation, the T cell receptor (TCR) undergoes phase separation with the kinase Lck to mediate rapid T cell activation. However, the manner in which costimulating receptors regulate this process has remained unclear.

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