# Small histone differences help shape gene regulation during sperm development

- Source: Phys.org - latest science and technology news stories
- Published: 2026-11-09T00:10:01+00:00
- Category: Science
- Original: https://phys.org/news/2026-11-small-histone-differences-gene-sperm.html
- Canonical: https://groundlevelnews.com/story/small-histone-differences-help-shape-gene-regulation-during-sperm-deve-542f94/

Researchers from Kyushu University have found that H3mm15, a histone H3.3 subvariant, contributes to normal sperm development in mice by helping regulate gene expression during spermatogenesis. The findings show that H3mm15 cannot be interchanged with conventional H3.3; although the proteins differ at only three amino acids, they behave differently in chromatin, the DNA-protein structure that pack

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